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+--- Thread: Revolution Plus? (/showthread.php?tid=485)
Revolution Plus? - MUM_of_FLUFFY - 10-18-2020
I've been using Revolution on Fluffy monthly since I got him. He has no issues with selamectin (the active ingredient in Revolution). Recently I received a free sample pack of Revolution Plus which has selamectin + sarolaner. I'm hesitant and a bit fearful to use it because I don't know if Fluffy might have an adverse reaction to the sarolaner (which protects against paralysis ticks).
We do have paralysis ticks here on the east coast of Australia and Fluffy does have access to an outdoor enclosure. So there is a reason to consider using it. But I'm still wary of using a new drug on Fluffy...
I know that no-one can give me the answer to what I should do - I will need to work that out for myself.
But I am interested to know if anyone has used Revolution Plus or knows anything about the ingredient sarolaner?
I found this link and I'm a bit worried by the information it contains:
"Isoxazoline products have been associated with neurological adverse reactions, including muscle tremors, ataxia, and seizures in some dogs and cats"
https://www.fda.gov/animal-veterinary/animal-health-literacy/fact-sheet-pet-owners-and-veterinarians-about-potential-adverse-events-associated-isoxazoline-flea
UPDATE: I found another link https://vetmed.illinois.edu/pet_column/fda-alert-on-flea-medications/ which says:
What is causing the adverse reactions?
- William Witola is a parasitology expert at the College of Veterinary Medicine and he explains that, “Isoxazoline class medications bind to chloride channels in nerve and muscle cells, which blocks the transmission of neuronal signals, causing parasites to become paralyzed and die.”
- This mechanism of action occurs not only in insects, but also in mammals and other vertebrates to a lesser extent. Although, isoxazolines are significantly more potent in insects, Dr. Witola explains that, “they can still cause toxicity in mammals, depending on the animal’s physiological state, health, and history.”
RE: Revolution Plus? - Codysmom - 10-18-2020
I couldn't even use the normal Revolution on Mittens, she had a terrible allergic reaction to it, she would lose her hair at the application sight and keep scratching like mad, it would take about 6 months to get her back to normal. The others were okay on it. I don't think I ever used Revolution Plus.
I'd also not take the chance.
RE: Revolution Plus? - MUM_of_FLUFFY - 10-18-2020
(10-18-2020, 04:51 PM)Codysmom Wrote: I couldn't even use the normal Revolution on Mittens, she had a terrible allergic reaction to it, she would lose her hair at the application sight and keep scratching like mad, it would take about 6 months to get her back to normal. The others were okay on it. I don't think I ever used Revolution Plus.
I'd also not take the chance.
Thank-you so much for letting me know that Colleen - much appreciated!!! I also read reviews of normal Revolution and many owners stated they had similar reactions to your darling Mittens. They supplied photos of the application site, some of which were crusty and scabby.
My late dog Eddie had adverse reactions (including seizures) to many things which is why I'm so very cautious now...